Chemistry Research – Learning All the Techniques
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Chemistry Research – Learning All the Techniques

>>DEAN CHRIS MAKAROFF: I came to Miami because
it had a graduate program in chemistry, so my background is in biochemistry. Miami places
an emphasis on undergraduate education first, but it’s got the infrastructure here to do
scholarship and to do research.>>CAMERON WILLIAMS: I had a high school teacher
that was really influential. We learned about biochemistry in his class, and I participated
in the Science Olympiad. I found Dr. Page’s lab, and he did a lot of biochem research,
particularly with proteins.>>KATHERINE MAKAROFF: In high school I really
liked chemistry; it was one of my favorite courses. I just found it really interesting
the way that it kind of all connects with the human body.>>CAMERON WILLIAMS: The main goal of this
research project is to develop drugs that will deactivate metallo beta lactamases. They’re
proteins that bacteria produce, and those proteins break down antibiotics. So what we’re
looking to do is develop drugs that target those proteins and deactivate them.>>KATHERINE MAKAROFF: We’re adding polymers
onto proteins to see how we can stabilize them with different polymers. The main goal
is to eventually add the polymers to cellulase, which breaks down cellulose into glucose,
which is then used for biofuels.>>PROF. RICK PAGE: Current biofuels are made
by taking sugars from things like corn and other crops, taking the part that you would
eat of the corn, and using those sugars and feeding those to the yeast.>>KATHERINE MAKAROFF: The end goal is to get
a more stable cellulase, which can then be used for mass production in the industry,
and hopefully bring down that cost of producing the biofuels.>>PROF. RICK PAGE: Trying to take the cellulose,
corn stocks, grasses, wood chips, discarded cellulose that we typically would not use,
take that, and repurpose that, and actually turn that into biofuels that you can put in
your car.>>DEAN CHRIS MAKAROFF: By working with a faculty
member, the student then typically takes on a project related to that faculty member’s
research and scholarship.>>CAMERON WILLIAMS: In a classroom, you learn
very cut-and-dry procedures for solving problems. But in research, it forces you to think more
in-depth.>>DEAN CHRIS MAKAROFF: It’s that ability to
develop a hypothesis, to see what the problem is, and then design experiments to test that
hypothesis, collect data, and then analyze that data to see how it relates to the problem
we are trying to solve.>>KATHERINE MAKAROFF: Today I am going to
be running an activity assay to access the activity of the cellulase that we’ve grown
up, and added the polymers to, and then I’ll use our plate reader to access the various
levels of activity of each sample.>>PROF. RICK PAGE: We’re going to determine
whether or not it’s active. We’ve made some modifications to it; we’ve changed it in some
way. Has that made it better, has that made it worse, or is the activity remaining the
same?>>CAMERON WILLIAMS: Working in Dr. Page’s
lab has forced me to learn the skills that someone wouldn’t learn until they get into
graduate school.>>KATHERINE MAKAROFF: I’ve been trained on
a lot of different instruments that a lot of undergrads don’t get to see, and you see
usually more in the graduate level. We have a lot of nice equipment that once you’re trained
on you really get to just kind of go for it and use it on your own.>>DEAN CHRIS MAKAROFF: They learn all the
techniques, they’re able to go off and go to medical school, they can go to graduate
school. But again, they can do just about anything.>>CAMERON WILLIAMS: I’m being offered a position
at Lawrence Berkeley National Laboratory in California. I’ll be working at the advanced
light source synchrotron, which is basically a particle accelerator, and we’ll be doing
x-ray crystallography.>>KATHERINE MAKAROFF: I’m going to be attending
the University of Cincinnati Medical School, where I’ll get my MD degree.>>CAMERON WILLIAMS: I wouldn’t have been offered
that position without doing research with Dr. Page.

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2 thoughts on “Chemistry Research – Learning All the Techniques

  1. I have 82% marks in 10+2 in medical(84 in chemistry out of 100) can I get admission in your institute?I am from Jammu & Kashmir India.Reply fastly plz plz plz.

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